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Opana 40 mg tablet is a prescription medication that contains oxymorphone, an opioid pain reliever. It is used to treat moderate to severe pain that requires continuous around-the-clock treatment. Opana 40 mg tablet should only be used by people who have been prescribed it by a healthcare professional and should be taken exactly as directed. It is important to note that the Opana 40 mg tablet has a high potential for abuse and addiction.