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it is designed to release the medication slowly over time, providing long-lasting pain relief. It is important to use Opana ER as directed by your doctor and to be aware of the potential for addiction and overdose. Click here to buy Opana ER now Opana ER tablet is a prescription medication used to treat severe pain that requires round-the-clock treatment. It contains oxymorphone, which is an opioid pain medication. Opana ER works by attaching to specific receptors in the brain and spinal cord to decrease the sensation of pain. It is an extended-release tablet, which means that it is released slowly into the body over a period of time, providing long-lasting pain relief. However, it can also cause several side effects, including dizziness, nausea, vomiting, constipation, and respiratory depression.